DETECTION OF SPECIFIC ANTIBODIES USING MPT83-MPT63 FUSION PROTEIN IN PATIENTS WITH DESTRUCTIVE PULMONARY TUBERCULOSIS

Introduction. The development of effective test systems for tuberculosis (TB) diagnosis and the study factors influencing their sensitivity specificity constitute urgent tasks given unstable epidemiological situation with TB in Ukraine world. aimed to determine clinical laboratory features pulmonary that may affect IgG antibody detection human serum by immuno-enzyme system “IB-Chem Anti-Mycobacterium tuberculosis”, which was developed at Palladin Institute Biochemistry NAS uses recombinant fusion protein MPT83-MPT63 as an antigen. Methods. Sera 62 patients chemoresistant were tested antibodies using indirect enzyme-linked immunosorbent assay. Dependence obtained results on symptoms signs TB, frequency different types antibiotic resistance, cellular biochemical parameters blood analysed. Results. tuberculosis” detecting found 71.0%; it reached 81.3% destructive TB. Conclusion. should primarily be used changes lungs where diagnostic efficiency this reaches high indicators.